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1996-03-04
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Document 0738
DOCN M9640738
TI Influence of HIV epidemic on the incidence of Kaposi's sarcoma in
Zambian children.
DT 9604
AU Athale UH; Patil PS; Chintu C; Elem B; Department of Paediatrics and
Child Health, University Teaching; Hospital, School of Medicine,
University of Zambia, Lusaka,; Zambia.
SO J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):96-100.
Unique Identifier : AIDSLINE MED/96142207
AB Acquired immunodeficiency syndrome-associated Kaposi's sarcoma (KS) is
well documented in adults. However, very little information is available
about KS in the pediatric age group. A retrospectively study was
undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia, to
define the incidence and clinical profile of KS in Zambian children over
the last 13 years and to determine the influence, if any, of the current
human immunodeficiency virus (HIV) epidemic on the pattern of pediatric
KS. All the histopathological records from 1980 to 1992 were reviewed
and all cases of KS along with the total number of malignancies, both in
children and adults, were analyzed. Along with this, 17 of 23 case files
of pediatric KS patients treated at the UTH since 1984 were retrieved
and clinical details recorded. Of a total of 915 cases of KS, 85 (9.25%)
were in children < 14 years of age. The age ranged from 7 months to 14
years, with an average of 5.62 years; the male/female ratio was 1.76:1.
A significant increase in the incidence of pediatric KS has been
recorded since 1987 (p < 0.001). This coincides with the advent of the
HIV epidemic in the country. The disease was aggressive and fulminant in
pediatric patients. More than 80% HIV seropositivity was detected.
Children with blood transfusion-related HIV infection had cutaneous or
lymphocutaneous disease, indicating that the mode of acquisition of HIV
infection may influence the clinical appearance of KS. Thus,
HIV-associated KS in children is becoming a common entity in Zambia. An
urgent prospective epidemiologic study is needed to address this problem
in HIV-affected regions.
DE Adolescence Age Distribution Child Child, Preschool *Disease
Outbreaks Female Human HIV Infections/COMPLICATIONS/*EPIDEMIOLOGY
HIV Seropositivity/EPIDEMIOLOGY *HIV-1 Incidence Infant Male
Retrospective Studies Sarcoma, Kaposi's/COMPLICATIONS/*EPIDEMIOLOGY
Sex Distribution Zambia/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).